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-synuclein, and that is a primary element of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, that's an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) strain, suggest that dysfunction on the intracellular proteinase devices, like ubiquitin-proteasome program or lysosomal technique, which eliminates unwanted harmful

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